The Networks of Excellence Program grant recipients since 2004 are listed below by project title and principal coordinators. For information about each network, please click on the project title.
2024
Immune targets for the treatment of atrial fibrillation
- Matthias NAHRENDORF, Massachusetts General Hospital (USA)
- Stefan KAAB, Ludwig-Maximilians University Munich (Germany)
Calcification-Omics, Molecular Elucidation, & Therapeutics (COMET)
- Rajeev MALHOTRA, Massachusetts General Hospital (USA)
- Catherine SHANAHAN, King's College London (UK)
PRIORITY: cardio-laminoPathy: fRom pathomechanIsms tO peRsonalIzed TherapY
- Gisèle BONNE, Sorbonne Université, INSERM (France)
- Andrew LANDSTROM, Duke University School of Medicine (USA)
The Placenta in Maternal and Fetal Cardiovascular Health and Disease
- S. Ananth KARUMANCHI, Cedars-Sinai Medical Center (USA)
- Didier STAINIER, Max Planck Institute for Heart and Lung Research (Germany)
2023
BIOELECTRONICS FOR NEUROCARDIOLOGY-DIAGNOSIS & THERAPEUTICS
- David PATERSON, University of Oxford (UK)
- Kalyanam SHIVKUMAR, University of California, Los Angeles (USA)
A Translational Approach Towards Understanding Brain Waste Clearance in Cerebral Amyloid Angiopathy
- Matthias VAN OSCH, Leiden University Medical Center (Netherlands)
- Susanne VAN VELUW, Massachusetts General Hospital (USA)
Intravascular lipolysis and cardiometabolic disease: molecular physiology, vascular biology, and therapeutics
- Michael PLOUG, Copenhagen University (BRIC) and Copenhagen University Hospital (Rigshospitalet) (Denmark)
- Alan REMALEY, National Heart, Lung, and Blood Institute, National Institutes of Health (USA)
Xenogenic and exogenic pig organs for transplantation into humans
- Daniel GARRY, University of Minnesota (USA)
- Eckhard WOLF, Ludwig-Maximilians-Universität München, LMU (Germany)
2022
AtheroGEN
- Mete CIVELEK, University of Virginia School of Medicine (USA)
- Hester DEN RUIJTER, University Medical Center Utrecht (Netherlands)
Cellular and Molecular Drivers of Acute Aortic Dissections
- Dianna MILEWICZ, The University of Texas Health Science Center at Houston (USA)
- Toru SUZUKI, University of Leicester (UK)
CHECKPOINT ATHERO
- Willem MULDER, Radboud University Medical Center (Nijmegen) (Netherlands)
- Esther LUTGENS, MAYO CLINIC (USA)
International Network of Excellence on Brain Endothelium: A Nexus for Cerebral Small Vessel Disease
- Martin DICHGANS, Klinikum der Universität München (Germany)
- Frank FARACI, The University of Iowa (USA)
2021
Leducq Trans-Atlantic Network of Excellence On Circadian Effects in Stroke
- European Coordinator: Alastair BUCHAN, University of Oxford (UK)
- North American Coordinator: Eng LO, Massachusetts General Hospital (USA)
Recalibrating Mechanotransduction in Vascular Malformations
- European Coordinator: Miikka VIKKULA, de Duve Institute (Belgium)
- North American Coordinator: Luisa IRUELA-ARISPE, Northwestern University Feinberg School of Medicine (USA)
Cardiac Splicing as a Therapeutic Target (CASTT)
- European Coordinator: Michael GOTTHARDT, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC) (Germany)
- North American Coordinator: Leslie LEINWAND, The Regents of the University of Colorado (USA)
Brown Fat and Cardiovascular Health: Genetic Determinants and Molecular Mechanisms
- European Coordinator: Sadaf FAROOQI, University of Cambridge (UK)
- North American Coordinator: Robert GERSZTEN, Beth Israel Deaconess Medical Center (USA)
2020
B cells in Cardiovascular Disease
- European Coordinator: Christoph BINDER, Medical University of Vienna (Austria)
- North American Coordinator: Filip SWIRSKI, Icahn School of Medicine at Mount Sinai (USA)
Cytoskeletal regulation of cardiomyocyte homeostasis in health and disease
- European Coordinator: Lucie CARRIER, University Medical Center Hamburg (Germany)
- North American Coordinator: Benjamin PROSSER, Perelman School of Medicine, University of Pennsylvania (USA)
The Inflammatory-Fibrosis Axis in Ischemic Heart Failure: translating mechanisms into new diagnostics and therapeutics
- European Coordinator: Florian LEUSCHNER, Heidelberg University Hospital (Germany)
- North American Coordinator: Robert GROPLER, Washington University School of Medicine (USA)
Editing the Failing Heart
- European Coordinator: Wolfram ZIMMERMANN, University Medical Center Göttingen (Germany)
- North American Coordinator: Elizabeth MCNALLY, Northwestern University (USA)
2019
Cellular and systemic cholesterol transport in physiology and disease
- European Coordinator: Elina IKONEN, University of Helsinki (Finland)
- North American Coordinator: Peter TONTONOZ, University of California, Los Angeles (USA)
Fighting against sinus node dysfunction and associated arrhythmias
- European Coordinator: Matteo MANGONI, CNRS, Montpellier (France)
- North American Coordinator: Peter MOHLER, The Ohio State University, Columbus (USA)
Targeted Approaches for Prevention and Treatment of Anthracycline-Induced Cardiotoxicity
- European Coordinator: Emilio HIRSCH, Università degli Studi di Torino (Italy)
- North American Coordinator: Hossein ARDEHALI, Northwestern University, Chicago (USA)
Stroke-IMPaCT (Stroke – Immune Mediated Pathways and Cognitive Trajectories)
- European Coordinator: Stuart ALLAN, University of Manchester (UK)
- North American Coordinator: Marion BUCKWALTER, Stanford University (USA)
2018
Towards Precision Medicine with Human iPSCs for Cardiac Channelopathies
- European Coordinator: Peter SCHWARTZ, University of Pavia (Italy)
- North American Coordinator: Joseph WU, Stanford University School of Medicine, California (USA)
Transcription factor Klf2 and cardiovascular disease
- European Coordinator: Ralf ADAMS, Max Plank Institute for Molecular Biomedicine, Münster (Germany)
- North American Coordinator: Martin SCHWARTZ, Yale University, New Haven (USA) and University of Manchester (UK)
Defining the Roles of Smooth Muscle Cells and Other Extracellular Matrix Producing Cells in Late Stage Atherosclerotic Plaque Pathogenesis
- European Coordinator: Gerard PASTERKAMP, University Medical Center, Utrecht (Netherlands)
- North American Coordinator: Gary OWENS, University of Virginia, Charlottesville (USA)
Cure PhosphoLambaN induced Cardiomyopathy (Cure-PLaN)
- European Coordinator: Pieter DOEVENDANS, Netherlands Heart Institute, Utrecht (Netherlands)
- North American Coordinator: Evangelina KRANIAS, University of Cincinnati College of Medicine, Ohio (USA)
Clonal hematopoiesis and atherosclerosis
- European Coordinator: Oliver SOEHNLEIN, Ludwig Maximilians University, München (Germany)
- North American Coordinator: Alan TALL, Columbia University Medical Center, New York (USA)
2017
Gut Microbiome as a Target for the Treatment of Cardiometabolic Diseases
- European Coordinator: Fredrik BÄCKHED, University of Gothenburg, Gothenburg (Sweden)
- North American Coordinator: Stanley HAZEN, Cleveland Clinic Foundation, Cleveland, OH (USA)
The sodium channel as a therapeutic target for prevention of lethal cardiac arrhythmias
- European Coordinator: Connie R. BEZZINA, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands)
- North American Coordinator: Mario DELMAR, New York University School of Medicine, New York, NY (USA)
ATTRACT: Arterial flow as attractor for endothelial cell migration
- European Coordinator: Holger GERHARDT, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin (Germany)
- North American Coordinator: Douglas MARCHUK, Duke University Medical Center, Durham, NC (USA)
Redox Regulation of Cardiomyocyte Renewal
- European Coordinator: Miguel TORRES, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) (CNIC), Madrid (Spain)
- North American Coordinator: Hesham A. SADEK, University of Texas Southwestern Medical Center, Dallas, TX (USA)
Potassium in Hypertension
- European Coordinator: Robert FENTON, Aarhus University (Denmark)
- North American Coordinator: Paul WELLING, Johns Hopkins University, Baltimore, MD (USA)
2016
LEAN (Leducq Epigenetics of Atherosclerosis Network) Defining and targeting epigenetic pathways in monocytes and macrophages that contribute to cardiovascular disease.
- European Coordinator: Menno de WINTHER, Academic Medical center, University of Amsterdam (Netherlands)
- North American Coordinator: Christopher K. GLASS , The Regents of the University of California, San Diego, La Jolla, CA (USA)
Repolarization HeterogeneitY imaging for personalised Therapy of Heart ArrhythMia
- European Coordinator: Michel HAISSAGUERRE, University of Bordeaux, Pessac (France)
- North American Coordinator: Igor EFIMOV, Northwestern University, Chicago (USA)
Cellular and molecular drivers of cardiac fibrosis and remodelling in health and disease
- European Coordinator: Norbert HUBNER, Max-Delbrück Center for Molecular Medicine, Berlin (Germany)
- North American Coordinator: Jonathan G. SEIDMAN, Harvard Medical School, Boston (USA)
Targeting Mitochondria to Treat Heart Disease
- European Coordinator: Michel OVIZE, INSERM, Université Claude Bernard, Lyon (France)
- North American Coordinator: Elisabeth MURPHY, NIH NHLBI, Bethesda (USA)
Understanding the role of the perivascular space in cerebral small vessel disease
- European Coordinator: Joanna WARDLAW, University of Edinburgh (UK)
- North American Coordinator: Berislav ZLOKOVIC, University of Southern California, Los Angeles (USA)
2015
Modulating autophagy to treat cardiovascular disease
- European Coordinator: Luca SCORRANO, University of Padova, (Italy)
- North American Coordinator: Junichi SADOSHIMA, Rutgers New Jersey Medical School, Newark (USA)
Eliciting Heart Regeneration through Cardiomyocyte Division
- European Coordinator: Elly TANAKA, Research Institute of Molecular Pathology, Vienna (Austria)
- North American Coordinator: Kenneth POSS, Duke University Medical Center, Durham (USA)
Evoked Neuronal Activity: A New Therapy for Acute Ischemic Stroke?
- European Coordinator: Matthias ENDRES, Charité University Medicine Berlin (Germany)
- North American Coordinator: Ron D. FROSTIG, University of California, Irvine (USA)
22q11.2 deletion syndrome: Novel approaches to understand cardiopharyngeal pathogenesis
- European Coordinator: Antonio BALDINI, Institute of Genetics and Biophysics, Naples (Italy)
- North American Coordinator: Bernice MORROW, Albert Einstein College of Medicine of Yeshiva University, Bronx (USA)
2014
Programming the Failing Heart to a Regenerative State
- European Coordinator: Mauro GIACCA, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
- North American Coordinator: Richard LEE, Brigham and Women's Hospital, Boston, Massachusetts, USA
Molecular Genetics, Pathogenesis and Protein-Replacement Therapy in Arrhythmogenic Cardiomyopathy
- European Coordinator: WILLIAM MCKENNA, University College of London, London, United Kingdom
- North American Coordinator: Ali J. MARIAN, University of Texas Health Sciences Center and Texas Heart Institute, Houston, Texas, USA
Sphingosine 1-Phosphate in Neurovascular Biology and Disease (SphingoNet)
- European Coordinator: Christer BETSHOLTZ, Uppsala University, Uppsala, Sweden
- North American Coordinator: Timothy HLA, Boston Children's Hospital, USA
Deciphering the Genomic Topology of Atrial Fibrillation
- European Coordinator: Vincent CHRISTOFFELS, Academic Medical Center (AMC), Amsterdam, Netherlands
- North American Coordinator: Patrick ELLINOR, Massachusetts General Hospital, Boston, Massachusetts, USA
2013
Cellular and Molecular Targets to Promote Therapeutic Cardiac Regeneration
- European Coordinator: David SASSOON, UPMC-Sorbonne Universités , Paris (France)
- North American Coordinator: Toren FINKEL, University of Pittsburgh, Pittsburgh (USA)
MicroRNA-based Therapeutic Strategies in Vascular Disease (MIRVAD)
- European Coordinator: Thomas THUM, Hannover Medical School (Germany)
- North American Coordinator: William SESSA, Yale University, New Haven (USA)
The function and regulation of PCSK9: a novel modulator of LDLR activity
- European Coordinator: Bo Angelin, Karolinska Institute, Stockholm (Sweden)
- North American Coordinator: Nabil G. SEIDAH, IRCM, Montreal (Canada)
Mechanical Triggers to Programmed Cell Death in Cardiomyocytes – and how to prevent their Action in Failing Hearts
- European Coordinator: Siegfried LABEIT, University of Heidelberg, Mannheim (Germany)
- North American Coordinator: Hendrikus GRANZIER, University of Arizona, Tucson (USA)
2012
Pathogenesis of Small vessel Disease of the Brain
- European Coordinator: Anne JOUTEL, INSERM, Université Paris 7- Denis Diderot (France)
- North American Coordinator: Mark T. NELSON, University of Vermont, Burlington (USA)
Understanding coronary artery disease genes
- European Coordinator: Heribert SCHUNKERT, University of Lübeck (Germany)
- North American Coordinator: A. Jake LUSIS, University of California, Los Angeles USA)
MIBAVA-Mechanistic Interrogation of Bicuspid Aortic Valve associated Aortopathy
- European Coordinator: Bart LOEYS, University of Antwerp (Belgium)
- North American Coordinator: Harry DIETZ, Johns Hopkins University, Baltimore (USA)
TNT-Triglyceride Metabolism in Obesity and Cardiovascular Disease
- European Coordinator: Rudolf ZECHNER, University of Graz (Austria)
- North American Coordinator: Stephen G. YOUNG, UCLA, Los Angeles (USA)
2011
Genomic, epigenomic and systems dissection of mechanisms underlying dilated cardiomyopathy
- European Coordinator: Stuart COOK, Imperial College, London (UK)
- North American Coordinator: Christine SEIDMAN, Harvard Medical School, Boston (USA)
Translating human pluripotent stem cells from heart disease models to cardiac repair
- European Coordinator: Michel PUCEAT, Université d'Aix-Marseille (France)
- North American Coordinator: Andre TERZIC, Mayo Clinic, Rochester (USA)
Lymph vessels in obesity and cardiovascular disease
- European Coordinator: Kari ALITALO, University of Helsinki (Finland)
- North American Coordinator: Mark KAHN, University of Pennsylvania, Philadelphia (USA)
Proteotoxicity: an unappreciated mechanism of heart disease and its potential for novel therapeutics
- European Coordinator: Mathias GAUTEL, King's College, London (UK)
- North American Coordinator: Jeffrey ROBBINS, Cincinnati Children's Hospital (USA)
2010
Transatlantic Network on newborn stroke: inflammatory modulation of neurovascular injury
- European Coordinator: Pierre GRESSENS, INSERM U676, Hôpital Robert Debré, Paris (France)
- North American Coordinator: Donna FERRIERO, University of California, San Francisco (USA)
Multidisciplinary program to elucidate the role of bone morphogenetic protein signaling
- European Coordinator: Nicholas MORRELL, University of Cambridge School of Clinical Medicine (UK)
- North American Coordinator: Kenneth BLOCH († 13/9/2014)/Donald B. BLOCH, Massachusetts General Hospital, Boston (USA)
Molecular mechanisms of novel genes associated with plasma lipids and cardiovascular disease
- European Coordinator: Christian WEBER, Ludwig-Maximilians-Universität (LMU) München (Germany)
- North American Coordinator: Daniel RADER, University of Pennsylvania School of Medicine, Philadelphia (USA)
High-density lipoprotein dysfunction in the development of cardiovascular disease and as a therapeutic target
- European Coordinator: Thomas LUSCHER, University of Zurich (Switzerland)
- North American Coordinator: Alan FOGELMAN, University of California, Los Angeles, David Geffen School of Medicine (USA)
2009
Redox and nitrosative regulation of cardiac remodeling: novel therapeutic approaches for heart failure
- European Coordinator: Ajay M. SHAH, King's College, London (UK)
- North American Coordinator: David A. KASS, Johns Hopkins University, Baltimore (USA)
Leducq Transatlantic Network on therapeutic arteriogenesis and metabolism modulation
- European Coordinator: Peter CARMELIET, Catholic University of Leuven (Belgium)
- North American Coordinator: Michael SIMONS, Yale University, New Haven (USA)
Structural alterations in the myocardium and the substrate for cardiac fibrillation
- European Coordinator: Stéphane HATEM, Université Pierre Marie Curie, Paris (France)
- North American Coordinator: José JALIFE, University of Michigan, Ann Arbor (USA)
Multi-scale modeling of single ventricle hearts for clinical decision support
- European Coordinator: Tain-Yen HSIA, Great Ormond Street Hospital for Children, London (UK)
- North American Coordinator: Richard FIGLIOLA, Clemson University (USA)
2008
Alliance for Calmodulin Kinase II Signaling in Heart Failure and Arrhythmias
- European Coordinator: Silvia G. PRIORI, University of Pavia (Italy)
- North American Coordinator: Mark E. ANDERSON, University of Iowa, Iowa City (USA)
Mechanisms matching the brain’s vascular energy supply to neural activity
- European Coordinator: David ATTWELL, University College London (UK)
- North American Coordinator: Brian MacVICAR, University of British Columbia, Vancouver (Canada)
MicroRNAs as therapeutic targets in heart failure
- European Coordinator: Stefan ENGELHARDT, Technische Universität München (Germany)
- North American Coordinator: Eric N. OLSON, UT Southwestern Medical Center, Dallas (USA)
2007
Transatlantic Network on Hypertension – Renal Salt Handling in the Control of Blood Pressure
- European Coordinator: Bernard C. ROSSIER, University of Lausanne (Switzerland)
- North American Coordinator: Steven C. HEBERT († 15/04/2008)/Richard LIFTON, Yale University, New Haven (USA)
Transatlantic Network of Excellence for the Identification of Novel Genetic Targets in Hemorrhagic Stroke
- European Coordinator: Elisabetta DEJANA, Institute of Molecular Oncology Foundation, Milan (Italy)
- North American Coordinator: Brant Michael WEINSTEIN, NIH/LMG, Bethesda (USA)
European-North American Atrial Fibrillation Research Alliance (ENAFRA)
- European Coordinator: Dobromir DOBREV, Duisburg-Essen University (Germany)
- North American Coordinator: Stanley NATTEL, Montreal Heart Institute (Canada)
Mitral Valve Disease: From Genetic Mechanisms to Improved Repair
- European Coordinator: Albert A. HAGEGE, Hôpital Européen Georges Pompidou, Paris (France)
- North American Coordinator: Robert A. LEVINE, Massachusetts General Hospital, Boston (USA)
2006
Defining the Mechanisms, Mediators and Clinical Applications of Remote Ischemic Preconditioning
- European Coordinator: Torsten TOFTEGAARD NIELSEN († 21/08/2011)/Hans Erik BOTKER, University of Aarhus (Denmark)
- North American Coordinator: Andrew REDINGTON, Hospital for Sick Children, Toronto (Canada)
Localized Control of cAMP Signaling and Novel Therapeutic Approaches for Heart Failure
- European Coordinator: Rodolphe FISCHMEISTER, INSERM/Université Paris-Sud, Châtenay-Malabry (France)
- North American Coordinator: John SCOTT, University of Washington, Seattle/Howard Hughes Medical Institute (USA)
Integrative Networks Regulating Cardiomyocyte Metabolism and Survival in Heart Failure and Insulin Resistance
- European Coordinator: Timothy AITMAN, Imperial College, London (UK)
- North American Coordinator: Anthony ROSENZWEIG, Beth Israel Deaconess Medical Center, Boston (USA)
Leducq Immunomodulation Network (LINK): Immune Modulation of Cardiovascular Disease
- European Coordinator: Seppo YLÄ-HERTTUALA, University of Eastern Finland, Kuopio
- North American Coordinator: Joseph WITZTUM, University of California, San Diego (USA)
2005
Preventing Sudden Cardiac Death
- European Coordinator: Denis ESCANDE († 13 November 2006)/Jean Jacques SCHOTT, INSERM U533, Nantes (France)
- North American Coordinator: Dan RODEN, Vanderbilt University, Nashville (USA)
Transatlantic Network on Pulmonary Vascular Remodeling: Early Determinants in Congenital Heart Disease
- European Coordinator: John HESS, Deutsches Herzzentrum München an der TU München (Germany)
- North American Coordinator: Jeffrey FINEMAN, University of California, San Francisco (USA)
Calcium Cycling and Novel Therapeutic Approaches for Heart Failure
- European Coordinator: Anne-Marie LOMPRE, INSERM U621, Paris (France)
- North American Coordinator: Andrew MARKS, Columbia University, New York (USA)
Adaptive and Maladaptive Signaling in Cardiac Growth and Regeneration
- European Coordinator: Helmut DREXLER († 13 September 2009)/Kai WOLLERT and Denise HILFIKER-KLEINER, Hannover Medical School (Germany)
- North American Coordinator: Jeffery D. MOLKENTIN, University of Cincinnati (USA)
2004
Leducq Transatlantic Network of Excellence on Atherothrombosis Research (LENA)
- European Coordinator: Jean-Baptiste MICHEL, Hôpital Bichat, INSERM Unit 460, Paris (France)
- North American Coordinator: Peter LIBBY, Brigham & Women's Hospital and Harvard Medical School, Boston (USA)
Leducq International Network Against Thrombosis (LINAT)
- European Coordinator: Frits R. ROSENDAAL, Leiden University Medical Center (The Netherlands)
- North American Coordinator: Edwin G. BOVILL, University of Vermont, Burlington (USA)
Transatlantic Network of Excellence for Cardiac Regeneration
- European Coordinator: Stefanie DIMMELER, J.W. Goethe-University, Frankfurt (Germany)
- North American Coordinator: Michael D. SCHNEIDER, formerly Baylor College of Medicine, Houston (USA); now Imperial College, London (UK)
Heart Progenitors in Cardiovascular Development and Disease: Cardiac Progenitors Transatlantic Alliance (CAPTAA)
- European Coordinator: Ketty SCHWARTZ, Groupe Hospitalier Pitié-Salpêtrière, INSERM U582, Paris († 26/12/2007) / Philippe MENASCHE, Hôpital Européen G. Pompidou, INSERM U633, Paris (France)
- North American Coordinator: Kenneth R. CHIEN, University of California at San Diego (USA)